Medical Options for Premature Ejaculation: What Works and What to Discuss with Your Doctor

TL;DR

Medical options include topical anesthetics, certain SSRIs, and dapoxetine (short‑acting SSRI in some countries). Medications can help when behavioral methods aren’t enough, but they carry side effects and should be discussed with a clinician.

Editor’s note

This article outlines medical options; it is not medical advice. Always consult a clinician before starting medication.

Topical anesthetics

Topical creams or sprays (lidocaine/prilocaine) reduce penile sensitivity and can delay ejaculation. Use as directed and be cautious about transfer to partner; many products advise washing off before intercourse or using a condom.

Oral medications

• SSRIs (selective serotonin reuptake inhibitors): Some SSRIs have the side‑effect of delayed ejaculation and are used off‑label for PE. They can be taken daily.
• Dapoxetine: a short‑acting SSRI developed for on‑demand use in PE; approved in some countries and prescribed as needed before intercourse.

Combination approaches

Behavioral therapy plus short‑term medication often has better results than either alone. For example, combining pelvic floor work with dapoxetine may produce additive benefits.

Side effects and safety

Discuss side effects (nausea, dizziness, sexual side effects) and drug interactions with your clinician. Avoid alcohol when taking certain agents and check for contraindications.

When to consider referral

If PE coexists with ED, pain, or urinary symptoms, a urologic or endocrine workup may be appropriate. A sex therapist can help with psychological and relationship factors.

FAQ

Are medications permanent fixes?

Medications can control symptoms while taken; combining with behavioral work increases the chance of durable improvement.

Is dapoxetine available everywhere?

Availability varies; check with your clinician and local regulations.

Sources

• Clinical trials and reviews on pharmacologic treatments for PE